生物标志物胍基乙酸与肌酸的研究进展

doi:10.3969/j.issn.1000-1158.2023.10.21

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Abstract Guanidineacetic acid (GAA) and creatine (CRE), as endogenous substances of human, themselves and their related metabolites are responsible for important physiological functions, and their content and composition have an impact on human tissues and organs. GAA is the precursor of CRE, and CRE can combine with adenosine triphosphate under the action of creatine kinase to form creatine phosphate, which is the material basis for energy storage and utilization in human body. In addition, GAA and CRE are also related to the occurrence and progression of many genetic metabolic diseases, and their rapid detection is essential for the early detection and treatment of such diseases. The currently known diseases correlated with GAA and CRE and their treatment methods are reviewed systematically. The modern detection methods of GAA and CRE in biological samples are also summarized and reviewed, and their possible developmental trends in the future are prospected.

Key words： metrolog gyuanidineacetic acid creatine creatine deficiency syndrome

Received: 27 December 2021 Published: 10 October 2023

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TB99

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	LIU Ruo-yi
	XIE Jie
	QIAO Xiao-ting
	JIANG You
	HUANG Ze-jian
	DAI Xin-hua
	FANG Xiang
	YE Zi-hong

Cite this article:

LIU Ruo-yi,XIE Jie,QIAO Xiao-ting, et al. Research Progress on the Detection Methods of Guanidinoacetic Acid and Creatine in Biological Samples[J]. Acta Metrologica Sinica, 2023, 44(10): 1631-1638.

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http://jlxb.china-csm.org:81/Jwk_jlxb/EN/10.3969/j.issn.1000-1158.2023.10.21 OR http://jlxb.china-csm.org:81/Jwk_jlxb/EN/Y2023/V44/I10/1631

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